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pentobarbital will reduce the level or effect of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.pentobarbital improves toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers may perhaps increase the metabolism of ifosfamide to its Energet